13th June
09h30 – 10h30Registration
10h30 – 10h45Opening session
Célia Duarte Cruz
Department of Biomedicine – Experimental Biology Unit, Faculty of Medicine, University of Porto
10h45 – 11h30Enhancing fiber growth and functional recovery by suppression of the growth inhibitor Nogo-A
Martin Schwab
Institute for Regenerative Medicine, University of Zürich; Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland
11h30 – 12h00Coffee break with poster viewing
12h00 – 13h00Oral communications
Spinal cord injury induced-sprouting of bladder sensory afferents is independent of the high repulsive spinal environment
Sílvia Chambel
FMUP/i3S
Secretome-Hydrogels as tools for SCI Repair
António Salgado
ICVS – UMinho
Spinal cord regeneration in animal models: what can we learn from zebrafish?
Leonor Saúde
IMM
13h00 – 14h30Lunch break
14h30 – 15h15Neuromodulation of Spinal Circuits: Neurorehabiliation and Recovery of Function following severe SCI
Ronaldo Ichiyama
School of Biomedical Sciences, University of Leeds, UK
15h15 – 16h15Oral communications
Translating Acomys to Mus: identifying the roadmap that enables axon regeneration in mammals
Joana Nogueira Rodrigues
i3S
The impact of Spinal Cord Injury in the immune response
Susana Monteiro
ICVS – UMinho
Regenerative and synaptogenic effect of human umbilical cord perivascular cells’ secretome in central nervous system neurons
Diogo Tomé
IBIMED – UAveiro
16h15 – 16h45Coffee break with poster viewing
16h45 – 17h15Oral communications
Novel neurotargeted nucleic acid delivery vector as a therapeutic tool to tackle neurological disorders
Ana Spencer
i3S
Efficacy of intrathecal baclofen therapy in spinal cord injury patients- a retrospective study of a portuguese population
Xénia Verraest
Centro de Medicina de Reabilitação da Região Centro – Rovisco Pais
17h15 – 18h00SCIMBIONT – Spinal Cord Injury Rehabilitation: gut dysbiosis and immune biomarkers as functional prognosis tools and new therapeutic targets
Maria Ribeiro Cunha
Centro de Reabilitação do Norte, Centro Hospitalar Vila Nova de Gaia – Espinho; Departamento de Ciências Médicas/Escola Superior de Saúde, Universidade de Aveiro
18h00 – 18h15Concluding remarks
14th June
09h00-12h00Workshop with Professor Martin Schwab
Limited to 25 participants, on first come, first served basis.
TRANSLATION FROM BENCH TO BEDSIDE FOR SPINAL CORD INJURY:
WHAT ARE THE MANY STEPS OF DRUG DEVELOPMENT AND CLINICAL TRIAL PLANNING?
The workshop offers a comprehensive overview of the steps required for translating a novel therapeutic approach ‘from bench to bedside’, i.e. from the level of a scientific discovery in vitro or in an animal model to clinical trials.
The different steps of drug development, regulatory interactions and clinical trial planning will be illustrated with the example of the regeneration enhancing anti-Nogo-A antibody therapies which have reached the level of Phase 2 clinical trials.
Workshop participants will be asked to contribute and discuss their own examples of novel potential therapeutic approaches for spinal cord injury.